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HIV self-testing kit, financial incentives increase men’s linkage to care, prevention services

Partner-delivered HIV self-testing kits and a fixed financial incentive substantially increased the odds of linkage to care or prevention services among men in Malawi, according to study findings.“Providing pregnant women an Oral self-test kit to take home for their male partner significantly improved HIV testing among the men,”Augustine T. Choko, MSc, statistical epidemiologist for the Malawi Liverpool Wellcome Trust Clinical Research Programme, told Infectious Disease News.

Between Aug. 8, 2016, and June 30, 2017, Choko and colleagues conducted an adaptive, multiarm, two-stage cluster randomized trial, enrolling women aged 18 years or older who were attending an antenatal care clinic (ANC) for the first time for their current pregnancy — regardless of trimester — with a primary male partner who was not on ART.

According to the study, the primary outcome was the proportion of male partners tested for HIV and linked to care, such as a referral for ART, or prevention services, such as voluntary circumcision, within 28 days.Women were randomly assigned to receive either the standard of care, which included an invitation letter for the male partner to attend a clinic, or one of five interventions.

All the women in the intervention arms were provided with two HIV self-testing kits for their partners, a clinic invitation letter and access to the clinic. Participants the in second and third intervention arms also received a conditional financial incentive of $3 or $10, whereas those in the fourth intervention arm were entered in a lottery with a 10% chance of winning $30. Those in the fifth intervention arm received a phone call reminder.

At day 28, women were interviewed about partner testing and adverse events.According to the study, 2,349 women participated in the study. Of the male partners, 43.7% had never been tested for HIV before.

In the standard-of-care arm, 17.4% of male partners went on to be tested for HIV — a much lower proportion than the intervention arms, in which HIV testing rates were between 87% and 95.4%.Among those receiving fixed financial incentives or a phone call plus HIV self-testing kits, more partners met the primary endpoint compared with those receiving the standard of care. Among participants in the standard-of-care arm or fourth intervention arm, Choko and colleagues observed no significant increase in meeting the primary endpoint.

Therefore, at the interim analysis, the lottery intervention arm was dropped.According to the study, 46 male partners tested positive for HIV and 91.3% of them initiated ART within 28 days. Of the 222 who were not already circumcised and tested negative for HIV, 60.8% were circumcised as part of the trial.

The researchers reported no serious adverse events.Choko and colleagues said the study was limited by the small clusters, proxy reporting of the outcome of the male partner testing and not having the ability to evaluate retention in care. However, among those receiving testing kits and the $3 or $10 incentive, costs per male partner with a positive HIV test result were $23.73 and $28.08, respectively.

The researchers suggest that these combinations were “potentially affordable.”“Combining the offer of a self-test kit with a financial incentive conditional on clinic attendance significantly improved HIV treatment and circumcision rates among the men,” Choko said. “Further research must look at what other additional interventions than monetary incentives would be acceptable to improve clinic attendance following HIV self-testing in the community.” – by Marley Ghizzone


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